Prozac capsules and syrup, from Eli Lilly & Co, are now also indicated for the treatment of pre-menstrual dysphoric disorder (PMDD). The recommended dose for treatment is 20mg/day. Initial treatment should be limited to six months, after which patients should be reassessed regarding the benefit of continued therapy. In clinical trials, the product was found to be effective in relieving both the cyclical mood changes and physical symptoms (eg, tension, irritability, bloating and breast tenderness) associated with PMDD (see p477).