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The Pharmaceutical Journal Vol 266 No 7154 p873-877
June 30, 2001

Clinical Pharmacy News summary


Protective effect of fibre against cancer confirmed

A fibre-rich diet does, after all, reduce the risk of developing colorectal cancer, a large European study has shown. The EPIC (European Prospective Investigation of Cancer and Nutrition) study involved 400,000 people in nine countries. The group that consumed the most fibre reduced their risk of colorectal cancer by as much as 40 per cent.

The findings contradict recent reports suggesting that high fibre consumption does not have a protective effect. Professor Nick Day, head of the EPIC team, University of Cambridge, commented that those results were based on much narrower studies than EPIC. “The people recruited for EPIC have much greater variations in their eating habits. This wide-ranging study is likely to give us a much truer picture of the links between diet and cancer,” he said.

The EPIC study also confirmed that eating fruit and vegetables reduces the incidence of cancers of the colon, rectum and upper respiratory/digestive tract. However, protection against stomach and lung cancer was not confirmed. Daily consumption of 500g or more of fruit and vegetables is sufficient to reduce the incidence of upper respiratory/digestive cancer by 50 per cent. Colon cancer risk was increased by high consumption of preserved meats, such as ham, bacon and salami, and reduced by high fish consumption. Red meat and poultry did not seem to be associated with an increased risk of colon or rectum cancer. Commenting on the results, Professor Gordon McVie, director general, Cancer Research Campaign, said: “We should all now aim to include wholegrain bread and cereals as well as the recommended five portions of fruit and vegetables in our daily diet.”

The worst news concerned alcohol and tobacco. EPIC found that smoking a pack of cigarettes a day increased the risk of upper respiratory/digestive cancer by eight times and that a daily alcohol intake equivalent to one standard bottle of wine increased the risk by nine times. However, the risk was increased by 50 times for people who both smoked and drank these amounts.

The EPIC results were presented last week at a European conference on nutrition and cancer in Lyons, France.

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