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The Pharmaceutical Journal Vol 267 No 7162 p251-255
25 August 2001

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Some good news about statins

Use of statins might be associated with a lower risk of age-related macular degeneration, say researchers from Southampton General Hospital.

In a survey of 379 men and women, 4 per cent of subjects taking statins (n=27) showed signs of macular degeneration compared with 22 per cent of subjects who did not take statins (n=352, P=0.02). The researchers say that statins might prevent the accumulation of abnormal deposits in the eye, which occurs when plasma cholesterol is raised.

Another proposed mechanism is that the antioxidant effect of statins might protect the outer retina from damage. Alternatively, the preservation of ischaemic vasculature, shown in a previous study to occur with simvastatin use, might maintain the blood supply to the macula (BMJ 2001;323:375).

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