The Pharmaceutical Journal Vol 267 No 7165 p337-341
15 September 2001

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Benefits of chemoradiation

Concurrent chemotherapy and radiotherapy improves survival rate in women with cervical cancer compared with radiotherapy alone, a systematic review of 19 studies has concluded.

The absolute benefit for chemoradiation in progression-free survival was 16 per cent and in overall survival was 12 per cent. The rate of local recurrence was significantly reduced by chemoradiation. In addition, chemoradiation resulted in a significant reduction in the rate of development of distant metastases.

The authors comment that this effect on distant metastases was not apparent in individual trials (Lancet 2001;358:781).

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