The Pharmaceutical Journal
Vol 268 No 7185 p206
16 February 2002
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Prescription ProductsComposition: Telithromycin 400mg. Presentation: Film-coated tablets. Class: Ketolide antibiotic. Indications: In patients aged 18 years and older, telithromycin is indicated for the treatment of the following infections: mild or moderate community-acquired pneumonia; acute exacerbation of chronic bronchitis; acute sinusitis; tonsillitis or pharyngitis caused by Group A beta haemolytic streptococci, as an alternative when beta-lactam antibiotics are not appropriate. In patients aged 12 to 18 years of age, telithromycin is indicated for the treatment of tonsillitis or pharyngitis caused by Group A beta haemo-lytic streptococci, as an alternative when beta-lactam antibiotics are not appropriate. Major cautions and contra-indications: Concomitant administration of any of the following with telithromycin is contraindicated: cisapride, ergot alkaloid derivatives, pimozide, astemizole and terfenadine. Telithromycin should not be used concomitantly with simvastatin, atorvastatin or lovastatin. Telithromycin is contraindicated in patients with a history of congenital or family history of long QT syndrome (if not excluded by electrocardiogram) and in patients with known acquired QT interval prolongation. Telithromycin should not be used during pregnancy unless clearly necessary and should not be used by breast-feeding women. Legal category: POM. Net price: 400mg 10 £19.31. Contact details: Aventis Pharma, Aventis House, 50 Kings Hill Avenue, Kings Hill, West Malling, Kent ME19 4AH. Tel 01732 584493. See SPC for further details. Composition: Tenofovir disoproxil (as fumarate) 245mg. Presentation: Film-coated tablets. Class: Nucleotide analogue. Indications: For use in combination with other antiretroviral agents in HIV-infected patients over 18 years of age experiencing virological failure. Major cautions and contra-indications: Tenofovir disoproxil is contraindicated in severe renal impairment. Caution should be exercised when: treating elderly patients; administering regimens containing nucleoside analogues and tenofovir disoproxil; administering tenofovir disoproxil to patients with mild to moderate renal insufficiency. Concomitant use of tenofovir disoproxil with medicinal products which are secreted by the same renal transporter (eg, cisofovir) is not recommended. Tenofovir disoproxil must be taken with food and should be used during pregnancy only if the potential benefit justifies the potential risk to the foetus. It is recommended that mothers being treated with tenofovir disoproxil do not breast-feed their infants. Side effects: Very common adverse events (>10 per cent) are diarrhoea, nausea, vomiting and hypophosphataemia; a common event (>1 per cent, <10 per cent) is flatulence. Legal category: POM. Net price: 30 tablets £255. Contact details: Gilead Sciences International, Granta Park, Abington, Cambridgeshire CB1 6GT. Tel 01223 897300. See SPC for further details. Generics (UK) has launched the following products: • Terazosin tablets; net price, 5mg 28 £13.07, 10mg 28 £26.59 • Cetirizine 10mg £8.73 The following products are now being supplied in Alpharma livery: • Amitriptyline 50mg tablets, pack size 28 • Dispersible aspirin 300mg tablets, pack size 100 • Ferrous sulphate 200mg tablets, pack size 28 • Gliclazide 80mg tablets, pack size 28 • Paracetamol 500mg tablets, pack sizes 30 and 100 • Thyroxine 50µg tablets, pack size 28 The following products are now available from Lagap Pharmaceuticals: • Domperidone 10mg tablets; net price, 30 £2.53 100 £8.40 • Bedranol SR (propranolol hydro-chloride) 80mg capsules; net price, 28 £7.48 • Tenoxicam 20mg tablets; net price, 28 £13.47 The packaging for Hormonin (estradiol 600µg, estriol 270µg, estrone 1.4mg) tablets has been changed from a securitainer containing 90 tablets to a blister pack in a carton containing 84 tablets (Shire Pharmaceuticals); net price, 84 £6.61. Stocks of the securitainer packaging are expected to run out by the end of February. |
Discontinued productsSulparex (sulpiride) 200mg tablets have been discontinued (Bristol-Myers Squibb Pharmaceuticals). Supply of Forcaltonin (recombinant salmon calcitonin) 100iu/ml solution for injection, 1ml apoules, will cease on March 30 (Strakan). |
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