Home > PJ (current issue) > Onlooker | Search

Return to PJ Online Home Page

The Pharmaceutical Journal
Vol 268 No 7188 p342
9 March 2002

This article
Reprint
Photocopy

   

PDF* 85K

Onlooker

Under the weather [more]
Remember mother [more]
Bioterror problem [more]


Under the weather

We often hear about that strange seasonal affective disorder (SAD), which is depression brought about by deprivation of light. But SAD is only one aspect of the repercussion of climatic conditions on the human spirit.

Indeed, Hippocrates in his essay "Of airs, waters and places", written in the fourth century BC, remarks on how the weather affects people: "In towns frequently exposed to winds, such as those which blow between the east and the west, and which are sheltered from the north winds, the slightest cause can change sores into ulcers. The inhabitants lack force and vigour, the women are sickly and voluntarily barren, the children are attacked with convulsions or sacral disease, the men are subject to dysentery, to long fevers in the winter." Centuries later, Voltaire commented that in London the east wind was responsible for suicides.

In Antarctica in 1912, Robert Scott and his companions, although only a dozen miles from a food depot, lost their capacity for clear thinking and action after being caught in a blizzard. We cannot discount the weather conditions when we discuss variations in different sicknesses.

It has been reported that dry climates are favourable and humid ones unfavourable to the progress of pneumonia. Women are more susceptible than men to this affliction, the difference being attributed to the fact that they had to wear more clothes. Any factor that affects the loss of body heat also affects recovery from febrile conditions. Moreover, abrupt changes in the weather may have effects on humoral and cellular immunity, which influence respiratory function.

In general, it is believed that the ease or difficulty in losing body heat determines physical and mental exertion. When obstacles are placed in the way of heat transfer all body functions and general vitality are reduced and there is a trend towards a vegetative existence. When heat loss is facilitated, however, growth, development and daily activity are increased, to our advantage.

When climatic conditions involve relatively large variations in atmospheric pressure, body chilling is likely to occur, bringing more colds, sinusitis, bronchitis, asthma, pneumonia, and even tuberculosis. It has been noted that an increase in appendicitis, eclampsia and rheumatic disorders may follow the passage of storm fronts over a region. Under milder conditions, sunshine, rainfall and wind velocity appear to exert a minor influence on bodily function, but may have more impressive effects on mental stability. Toxic goitre and diabetes have been attributed in part to a climatic drive which forces people into efforts to make more haste, so that they outstrip their capacity to adapt.

Mental and emotional instability seems to be influenced by severe instability in the weather. With the approach of falling barometric pressure, many people experience a sense of futility and an inability to perform with their usual mental efficiency, although they may not realise its origin. Children may become irritable and petulant, adults grow quarrelsome. With the passing of the atmospheric depression, mental depression makes way for confidence, even exuberance.

At times of low ebb, individuals may turn to pharmacological resources. It is true that drugs of the amphetamine family, in particular, bring enormous relief when one is under the weather, but to have recourse to them without pressing need is dangerous. Even the safer ones, such as methylphenidate, must not be abused, and the more hazardous ones like "ecstasy" must be kept out of the hands of adolescents.

Back to Top


Remember mother

I am reminded that the celebration which we call in modern parlance Mother's Day or Mothering Sunday falls this year on 10 March. It was originally entitled Mid-Lent Sunday, corresponding to the fourth Sunday in Lent, or dominica refectionis, since the text for the day is the feeding of the five thousand.

It was an occasion for indulging in simnel cakes, a rich product containing almonds and eggs and decorated with marzipan. It was also expected that children and older youngsters living away from their parents would return home for the day, taking presents, including a cake for their mother, and sharing a meal with the rest of the family before going back to their workplace. The tradition dates back to the mid-17th century, and by the 20th century another had arisen, when the clergy handed out posies of flowers and pieces of cake to their young parishioners to take home to their mothers.

A variant of the ceremony arose in Philadelphia, where Anna Jarvis persuaded Congress in 1913 to dedicate the second Sunday in May to honouring motherhood. This idea spread to some extent into Britain during the Second World War, but seems never to have replaced the older tradition. The commercial interest has invaded the field, and honouring mother is a profitable activity, particularly for florists.

Back to Top


Bioterror problem

The problems posed by the newer terrorist tactics such as distributing anthrax spores by way of letters and parcels are probably insoluble unless expensive and antisocial measures can be taken. In our violent and unethical world no one can be sure that some underground organisation is not at some time or other producing biological weapons with the aim of employing them to create fear and havoc. Techniques for preparing bacterial cultures are widely available, and much is known about methods of producing from them preparations designed for transmission by various routes and almost guaranteed to induce serious illness or death.

In Science for 22 February is a summary of the issues raised in the United States by the distribution of preparations of anthrax spores through the regular postal service. In the past precautions taken by postal authorities have largely been directed at preventing transmission of explosive devices. Screening that will minimise this danger is well understood and not too difficult to apply. But when biological agents are involved, "postal authorities are in largely uncharted waters''. Elimination of a possible biohazard must be cost-effective and compatible with normal postal operations of sorting and delivery.

Various techniques are currently available for "sanitising" mail items. They include electron beaming, X-rays, gamma radiation, ultraviolet illumination, heating and exposure to certain gases. Only ionising irradiation is rapid and penetrating enough to treat differently sized and shaped mail items, but the dose needed to assure anthrax destruction is liable to damage medicines and medical specimens, plant seeds, foods, plastics and paper documents. Moreover, irradiation can produce volatile organic compounds and induce sickness in some postal workers.

Safeguards against such undesirable repercussions are called for. The quantity of mail needing treatment might be reduced if reliable senders could be offered exemption from the routine treatment, but this is obviously a tricky element in the process. Photographs or fingerprints have been suggested as a precaution to be taken at the time of shipment. Whatever is adopted, some degree of inconvenience and intrusion into personal or commercial confidence measures would result. Costs and benefits will need to be set against one another, and the tolerance of the suffering public will be sorely tested.

Back to Top



Home | Journals | News | Notice-board | Search | Jobs  Classifieds | Site Map | Contact us

©The Pharmaceutical Journal