Prescription Products
Arixtra injection
Composition: Fondaparinux sodium 2.5mg/0.5ml.
Presentation: Solution for injection.
Class: Antithrombotic agent.
Indications: Prevention of venous thromboembolic events in patients undergoing
major orthopaedic surgery of the lower limbs such as hip fracture, major
knee or hip replacement surgery.
Major cautions and contra-indications: Fondaparinux is contraindicated
in active clinically significant bleeding, acute bacterial endocarditis
and severe renal impairment (creatinine clearance <30ml/min). Fondaparinux
should be used with caution in patients with: moderate renal impairment;
severe hepatic impairment; a body weight of <50kg. It should also be
used with caution in the elderly and in patients who are at increased
risk of haemorrhage. The following agents should not be administered concomitantly
with fondaparinux: desirudin, fibrinolytic agents, glycoprotein IIb/IIIa
receptor antagonists, heparin, heparinoids and low molecular weight heparins.
Acetylsalicylic acid and other non-steroidal anti-inflammatory drugs,
dipyridamole, sulfinpyrazone, ticlopidine and clopidogrel should be used
with caution in patients taking fondaparinux. Fondaparinux should not
be prescribed to pregnant women unless clearly necessary and breastfeeding
is not recommended during treatment.
Side effects: Common (Ž1 per cent, <10 per cent) undesirable effects
include anaemia, bleeding (at surgical site, gastrointestinal, haematuria,
pulmonary, haematoma), thrombocytopenia, purura and oedema.
Legal category: POM.
Net price: 10 prefilled syringes £71.68.
Contact details: Sanofi-Synthelabo, One Onslow Street, Guildford, Surrey
GU1 4YS. Tel 01483 505515, fax 01483 535432.
See SPC for further details.
Zyvox oral suspension
Zyvox (linezolid) 100mg/5ml granules for oral suspension has been launched
(Pharmacia); net price, 150ml £222.50.
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