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The Pharmaceutical Journal
Vol 268 No 7203 p882
22 June 2002

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Onlooker

Balancing trick [more]
Ancient habit [more]
Green minds [more]


Balancing trick

A fascinating discussion of the concept of equilibrium, by Ivar Ekeland of the University of Paris, is published in Nature for 23 May.

Equilibrium, of course, has some close affinity with another concept, that of holism, which maintains that there is an essential interaction between all forces and objects in our universe, and that to tamper with one of them is to throw systems out of precise balance, with consequences that human planners prefer to ignore. Equilibrium is defined as "a situation in which a balance of conflicting forces results in rest". In thinking what we mean by rest, we usually choose to eliminate all forces, rather than visualise them as countering one another dynamically. Agents that settle decisions in nature interact in a complex manner. In the social sciences, which determine to a great extent our destinies, any equilibrium involves several individuals or groups where every unit of action represents the best reply to that of every other action.

Situations calling for equilibrium, argues Ekeland, are central to social life, because they alone are stable enough to sustain us. If anticipation of action in one quarter turns out to be faulty, the entire system tends to pass out of balance, and starts to oscillate between alternatives.

Social organisation basically relies on the two entities of power and trust. Power is really illusory, holding that certain persons are to be obeyed and certain orders followed without question, a situation that in the last resort spells violence. These concepts are to be observed in action at present in the Middle East and Asia, and also in Africa. Trust, however, is the belief that other people and other organisations will conform to certain rules of conduct, and to comply with such rules gives us a personal feeling of trust, whereas to flout them for selfish reasons results in distrust.

Just as trust engenders trust in others, so does distrust cross boundaries between individuals and communities. Accordingly, both trust and distrust can be regarded as examples of equilibrium.

In the universe of living beings natural selection is a method of bringing competing species into the state of equilibrium with one another, where the two come to stable adjustments and natural law is the means of arriving there. Our own ethics of behaviour and sense of justice, social habits and rights as individuals are not rooted in absolute truths or in human nature itself, but are determined ideally by the equilibrium which we or our society has reached. This principle needs to be remembered in our professional dealings and responsibilities as well as our personal day to day lives. 0Indeed, claims Ekeland, "our social fabric and our personal ethics, everything we stand for, rest on equilibria, which we conjure out of nothing. We are such stuff as dreams are made on." And with that comment of Prospero I am in full agreement.

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Ancient habit

A letter in The Lancet for 25 May from pharmacognosists and pharmacologists in Sweden makes some interesting observations on the great antiquity of the use of mescaline in early cultures. They comment that archaeological investigations in north-eastern Mexico and Trans-Pecos in Texas have indicated that the use of psychoactive drugs in that region dates back to around 8500BC. The aboriginal inhabitants of the region had recourse to the mescal bean (Sophora secundiflora) and buttons of the peyote cactus (Lophophora williamsii), natural products that contain the hallucinant mescaline and related tetrahydroisoquinoline alkaloids.

Peyote buttons from a Mexican site yielded a radiocarbon date of AD810–1070 and the presence of mescaline and its relatives. Two much older samples of peyote thought to have been obtained from Shumla Cave No 5 on the Rio Grande in Texas had a mean radiocarbon date of 3700BC. In both samples mescaline was detected by thin-layer chromatography and mass spectrometry. The writers of the letter state that freshly prepared peyote buttons may contain up to 8 per cent of total alkaloids, but in the previously examined millennium-old sample this had fallen to 2 per cent, with mescaline being the sole identifiable alkaloid. None of the other tetrahydroisoquinoline derivatives could be detected.

The peyote material appears to be the oldest plant drug that has yielded a major bioactive compound on chemical examination. This finding reinforces the evidence that as long ago as 5,700 years the natives of North and Central America recognised and used the hallucinant properties of peyote.

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Green minds

When we hear of people who talk to their plants to encourage them to grow or flower, we may set down the habit to an inexplicable idiosyncrasy. Yet it may not be so if we examine the habits plants exhibit of responding to many sorts of stimuli. An article from Anthony Trewavas of the Intitute of Cell and Molecular Biology of the University of Edinburgh, published in Nature for 21 February, discusses our acceptance of plants as passive creatures simply because they lack visible movement and seem bereft of behavioural intelligence. Our attitude, he writes, is strange, since plants comprise 99 per cent of our earth's biomass and dominate every landscape. Today, however, serious studies of plant intelligence are taking place, which will make us reconsider our attitude.

Since their evolutionary genesis, photosynthesising plants have enjoyed free access to light, but recent land development by humans has increased plant competition for light. Over the ages, shapes and numbers of stems, leaves, roots and types of tissue cells have undergone variation, and many environmental effects have brought their changes after many years. Yet, in the generation of organs and tissues there is evidence of the plasticity of plant habits.

Plants regularly screen at least 15 environmental variables, showing remarkable sensitivity to external factors. Internally, their cells and tissues communicate through proteins, nucleic acids, hormones, peptides, lipids and sugars, plus other mineral and mechanical signals, and a single signal brings greatly different responses in a cell, leading to different varieties of behaviour of the organism. If the function of intelligence is to improve fitness to exist, then this denotes plant intelligence.

A developing shoot can optimise reception of light and avoid competition from other plants. A developing rhizome can select a habitat with rich resources. Roots evaluate humidity and mineral elements, and can avoid competitors' root systems. The humble dodder exploits its host by touch and if neighbouring support is lacking, seeks further afield. Its estimate of host exploitation determines how many coils and suckers it deploys.

Can such intelligent behaviour be controlled without a brain at the centre. Possibly not, but, as in animals, calcium within cells mediates most plant signals, "and calcium waves inside cells offer computational possibilities". The meaning of this phrase is not clear to me but, as Trewavas concludes, a challenge has been set and remarkable discoveries lie ahead.

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