Home > PJ (current issue) > Onlooker | Search

Return to PJ Online Home Page

The Pharmaceutical Journal
Vol 269 No 7216 p392-394
21 September 2002

This article
Reprint
Photocopy

   

PDF* 50K

Onlooker

Art in peril [more]
DNA testing [more]
Health and economics [more]


Art in peril

Baldwin Brown in his 'The art of the cave dweller' (1928) describes how a landowner in the Santander province of northern Spain entered a cave on his estate which had been closed from time immemorial but newly revealed after quarrying operations in 1875. Here he discovered on the floor the footprints of a cave bear and black pigment on the walls. He neglected to look further, but in 1879 he again entered, accompanied by his seven-year-old daughter, who ventured further and excitedly told her father that there were pictures of beasts on the roof or plafond, and in particular a remarkable bull in colour. He was struck with the paintings of bison and boars, which afterwards brought the cavern of Altamirs into international repute.

Although the landowner published a report in 1880 there were many sceptics, and the cave was neglected for another two decades. Then its fame exploded, and the ease with which travellers could visit the site from the port of Santander brought flocks of sightseers. The 30 or so large paintings exposed were attributed to the Magdalenian period of 16,000BC to 10,000BC.

In the 1970s nearly 3,000 visitors were allowed daily, but with signs of deterioration this number was cut to 40 two decades ago. According to a report published in Science for 5 July, this precaution has proved insufficient to prevent decay of the pigments. Microbiological investigation in 1999 has shown that the cavern's galleries are scattered with colonies of actinobacteria. More recent DNA analysis has detected acidobacteria and proteobacteria, which grow on the red iron oxide pigments, and it is known that closely related strains are able to degrade haematite in laboratory cultures, causing depigmentation.

It is now recognised from experiences in other caves that an influx of visitors, taking with them exhaled water vapour and also possibly micro-organisms, is likely to prove disastrous for such priceless art treasures of our ancestors. Methods for protection are under examination. One might involve turning down the light intensity, since light stimulates algal growth, which gives the bacteria nutrients. It is still not understood, however, how the process of pigment deterioration and establishment of bacterial development is established. Meanwhile, the only remedy seems to be to exclude human visitors as far as possible.

Back to Top


DNA testing

When the subject of DNA testing for forensic purposes is raised there is always the hint of George Orwell's Big Brother in the background. This is perhaps an understandable shadow, when you consider the maze of strange regulations that is afflicting the civilised world, threatening to suppress individual endeavour and initiative. Yet the identification of individuals by studying their DNA is really nothing to be afraid of, provided it is not abused.

In Nature for 8 August two researchers from the University of Melbourne offer a lucid explanation of the virtues and the possibilities of this well-established biological investigation. The polymerase chain reaction (PCR) on which it depends is a well-established technique which when carried out by experienced operators gives reliable results, without artefacts. The latest gene amplification techniques allow a unique DNA match to be performed from a single nucleated blood cell, cheek epithelial cell, saliva, sperm, a hair follicle or skin cells present in a fingerprint.

The uses to which findings might be put constitute the reason why many people fear the investigation. It is feared that the test might violate privacy, so that governments, insurance companies, employers and other interested parties might wrongly access genetic information about us. People fear that contamination or error might lead to a wrongful conviction for some crime.

For this reason, specific safeguards are essential in DNA testing to eliminate misunderstanding and possible miscarriages of justice. Measures should ensure that laboratories responsible for testing are properly accredited and independent of the police, and periodically reassessed for reliability. Samples for testing should be sent directly to the testing laboratory, and if possible divided into two to permit access to defence as well as prosecution. Packaging should be tamper-proof. Samples should be destroyed after recording the DNA profile. Data should be kept in national or international databases, independent of police.

There are possible alternatives when it comes to actual sampling. Samples might be taken only from convicted criminals, from these and also suspects, or from everyone in the community, preferably at birth. The authors of the commentary maintain: "The most logical and fair practice — and also the most controversial — would be to DNA-test all individuals at birth. This would not only act as a deterrent from crime for all members of the community, but would make the task of catching criminals easier for police. If the correct safeguards are in place to protect civil liberties, why should a proposal to test everyone at birth be a frightening one? On the other hand, if the correct safeguards are not in place, and the fears are justified, why are we daring to test anyone at all?" That seems to me to be a logical question.

Back to Top


Health and economics

A rather unusual attitude to questions of health throughout the world is revealed in an editorial by the World Health Organization's director general, Gro Harlem Brundtland, published in the British Medical Journal for 24 August — just before the United Nations world summit on sustainable development. She points out that although sustainable development is concerned with climate change, rising sea levels, loss of biodiversity and spreading deserts, it also has repercussions on the future provision of food, shelter and health to every inhabitant of this planet.

Health, writes Dr Brundtland, has to be a priority in any discussion at a world summit on sustainable development, first because it is a means of stimulating economic growth, enabling the environment to be protected and poverty reduced. Then we can achieve greater precision in the measures we take to invest in health. We have more and more evidence on which to base strategies intended to reduce people's health risks, in particular those risks arising from environmental failures, to which children are particularly vulnerable — diseases arising from poor hygiene, domestic and traffic accidents, and exposure to such toxins as lead and pesticides. We must accept the need for long-term equitable access to those natural resources, which are critical to the health of individuals, even their life. Famine in southern Africa has revealed an urgent need to deal with pressures on food and water resources imposed by political conflict and exacerbated by racial and sex discrimination.

In moving the focus from mere wordy commitments to deeds we cannot rely upon economic growth alone to solve the problems aroused by poverty. Assistance in development, democratic change and fairer access to world markets are called for. And it is obvious that rich countries are quickly able to find millions of dollars for any cause which they can be persuaded is important. The global society has the necessary resources to overcome the impasse. Yet it has to find the will to carry out reforms.

Back to Top


Home | Journals | News | Notice-board | Search | Jobs  Classifieds | Site Map | Contact us

©The Pharmaceutical Journal