The Pharmaceutical Journal
Vol 269 No 7222 p637
2 November 2002

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Cancer Research UK (www.cancerresearchuk.org)

DNA-repair process disabled

A new class of drugs that disable the DNA-repair process after radiotherapy has been developed by researchers at the Cancer Research UK unit, Newcastle University.

The researchers explain that the drugs inhibit poly (ADP-ribose) polymerases, thus blocking the action of DNA repair and sensitising cancer cells to radiotherapy. The research was presented at the Cancer Research UK annual conference in Warwickshire this week.