The Pharmaceutical Journal
Vol 270 No 7244 p507
12 April 2003

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Elan Pharmaceuticals (www.elan.com)

Antiepileptic drug for obesity

Antiepileptic drug zonisamide plus a hypocaloric diet results in more weight loss than placebo plus a hypocaloric diet when used in the treatment of obesity, researchers report in JAMA this week (2003;289:1820). Zonisamide has serotonergic and doperminergic activity and weight loss is an adverse effect associated with the drug.

Zonisamide is manufactured by Elan Pharmaceuticals.