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The Pharmaceutical Journal
Vol 270 No 7248 p662
10 May 2003

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Onlooker

Paying the price [more]
Great chemist [more]
Peril and politics [more]


Paying the price

Those who speak loudest in this world, notably the politicians who have a falsely high opinion of their importance to the welfare of society, are in the habit of taking a blinkered and short-term view of the physical world in which they, and we, have to live. Climate is one factor that is largely ignored on the assumption, perhaps, that there is little or nothing humans can do about it.

The attitude of governments to climate change has never been attentive, unless a major change, temporary but real enough, produces a severe drought or a severe flood problem. Yet, as a review by scientists from a number of universities published in Science for 28 March indicates, there is such a thing as abrupt climate change that could have drastic effects on human affairs, and calls for urgent consideration. Policy-makers, claim the authors, should consider expanding research into abrupt changes, improve the systems available for monitoring them and take actions designed to enhance the response of ecosystems and economies.

For example, in the 20th century warming in many northern regions occurred in two abrupt steps, that suggests the juxtapositioning of natural causes and human-induced changes. The temperature on the Atlantic side of the Arctic in the 1920s rose by 4C or more in places, and during the following decade the United States suffered extended drought, with a serious effect on agriculture. An abrupt shift in climate in the Pacific region in 1976–77 triggered oceanic and coastal temperature changes in the Americas. Low-salinity deep waters affected the seas between Greenland and Europe. Centuries before, the effects of drought caused the collapse of the Mayan civilisation and the Akkadian empire. It is considered that human activity may be the impetus that upsets climatic equilibrium and so produces an abrupt change in climate.

Loss of vegetation by over-exploitation of natural resources reduces the ability of roots to capture water, and promotes run-off of surface water to streams and oceans; this may produce a desert. Although most ecological and economic systems are able to adapt to a gradual change, abrupt changes may cause permanent damage, particularly in systems with a long lifetime or some immobility. Human activity is liable to prove the last straw in disturbing an equilibrium. For example, over 10,000 years ago, many large North American mammals, which had been able to survive previous climate variations during their history, being stressed by yet another abrupt change, succumbed to the pressure of being hunted relentlessly. The habitat fragmentation induced by human expansion impeded migration and increased the vulnerability of some ecological systems previously in equilibrium. If human activities are driving a climatic system towards a threshold point where disequilibrium occurs, the next century will see abrupt climate change calling for drastic action.

Effective strategies can be devised to counteract such effects. For instance, in the so-called Little Ice Age the Viking settlements in Greenland became extinct, while the neighbouring Inuit culture survived, thanks to a successful strategy.

As the authors of the report comment: "Any future abrupt climate change might have large and unanticipated impacts. Improved understanding of the processes may increase the lead time for mitigation and adaptation." Whether our industrialists and economists will try to understand the situation our children have to face, if we continue to use natural resources at the same rate as now, is questionable.

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Great chemist

Justus von Liebig was born 200 years ago, on 12 May 1803, in Darmstadt, Germany. He became engrossed with chemistry at an early age, to the dismay of his teachers, who considered that he was neglecting his other studies in order to concentrate his attention on his pet subject. At the age of 15 he was apprenticed to a pharmacist, but soon abandoned that career. His early studies were at Bonn and Erlangen. Then in 1822 he went to Paris to join the laboratory of Joseph Gay-Lussac, where he worked on mercury and silver fulminates and a range of cyanates.

In 1824 Liebig returned to Germany to Giessen, where he held the post of professor of chemistry. His laboratory attracted many chemistry students of distinction, including Kekulé. In 1852 he moved to Munich, where he interested himself in agricultural chemistry and synthetic practice, in the course of which he discovered chloroform and chloral. Together with Friedrich Wohler he described the benzoyl radical. In his Giessen laboratory he greatly extended the methods of organic analysis, inventing in particular devices for studying combustion and the familiar condenser with which his name is associated.

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Peril and politics

The dismal story of the sudden spread of the virus responsible for severe acute respiratory syndrome (SARS) should constitute a warning for those politicians who think that the economic effects of information on a country should be given priority over urgent matters of life and death.

We have heard how the syndrome apparently arose in the southern Chinese province of Guangdong last November, when a coronavirus was somehow transmitted from an undefined animal source to humans. A professor of medicine who had helped to deal with the outbreak travelled to Hong Kong, where he became febrile and requested hospital isolation. The hospital staff, who had heard only of a mysterious pneumonia outbreak in Guangdong, neglected to isolate him effectively, and the virus spread, first to the hospital staff, then to the hotel where the professor had stayed, and afterwards to Singapore, Vietnam, Canada and other places. Air travellers became suspect, and difficulties in transit became apparent.

All this happened because the Chinese authorities failed to report the outbreak, and have since admitted its mismanagement. Even the limited passing of information to people professionally concerned was classified as top secret, since the authorities thought that publicity shortly before the start of the Chinese New Year would impact upon the country's economy.

The World Health Organization operates a Global Outbreak and Response Network designed to ensure that information regarding disease outbreaks shall rapidly be circulated. However, there is a rule that officials of the network may enter a country to investigate only when given government permission, and may reveal details only with that government's consent. The effect of this is inevitably to delay world circulation of information that is vital and urgent if an epidemic arises. With a problem such as SARS, where a virus is passed on only through close personal contact, precautions can be taken and control measures applied, but only if information is passed between regions, and with the minimum of delay. It is a sad commentary on human affairs that artificial barriers between so-called civilised countries, erected merely to preserve trade and money, are able to sabotage our best efforts to rid people of killer diseases.

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