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The Pharmaceutical Journal
Vol 270 No 7252 p800
7 June 2003

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Onlooker

Common complaint [more]
Price of prions [more]
Change and decay [more]


Common complaint

We hear a great deal today about stress as a factor in unhealthy lives. It is something difficult to define or explain, and we nominate different aspects of it as emotional, physical, post-traumatic, competitive, occupational and so on until the very idea grows in complexity.

Why, we ask, have the aspects of stress become a major issue for discussion today? So far as physical peril and interpersonal arguments go, it can be argued that there must be less stress than our ancestors encountered, since we occupy a more civilised environment than ever before — supposing we set aside a few new developments such as terrorism and loutish misbehaviour. The primary stressors of cold, starvation and physical exhaustion are now rare in developed societies. On the other hand, the many new demands of technology make inroads on our peace of mind which our ancestors could not have imagined.

Measurable physiological changes enable us to assess how stressed we are. Secretion of cortisol and adrenaline is altered by any sensory overload or underload. A sense of helplessness in any situation that arises is a potent factor in provoking the mental stress that increases our risk of ill-health and altering the course of both somatic and mental disorders from which we may suffer minor disabilities. It is seldom possible, however, to pinpoint any specific stressor associated with our occupation or our leisure, and if we manage to do so the remedy may prove impracticable and the resultant sense of helplessness can only make things worse. A sense of having to compete with our fellows, allied to a sense of urgency less we be left behind in any endeavour, leads to deterioration of which we should beware.

Strangely enough, there are many ways in which, if we make an effort, we can reduce our susceptibility to stressors. They are so simple that most people tend to ignore or despise them. The main antidotes of which I am aware are practising music or painting in water-colours or oils, gardening, cooking, ironing, knitting, embroidery and other crafts that can be carried on quietly and without haste. Their great virtue, indeed, is that they cannot be hurried, since haste and competition are the things we need to avoid in seeking to diminish stress of living.

Several proverbial expressions are associated with the phenomenon of stress. There is "keeping up with the Joneses", a saying which originated in the United States as long ago as 1913, and which reflects the prevalent craze for cut-throat competition and showing-off.

Then we talk about "the rat race", meaning a relentless struggle to overcome rivals in business or in social circles. Why rats should be involved is not clear. They were regarded as sacred among the ancient Egyptians and Phrygians, but at the same time symbolising both wise judgement and sheer destructiveness. For the Romans the appearance of a rat might denote coming good or alternatively evil. And in later times the phenomenon of rats leaving a ship or an old house was ominous of destruction to come.

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Price of prions

A neurodegenerative disease called kuru or the "laughing sickness" attracted some notoriety 40 years ago when it attacked 10 per cent of a tribe in New Guinea called the Fore and proved almost invariably fatal.

The Fore occupied a remote highland region in the eastern highlands of Papua New Guinea which had previously had no contact with the outside world, but was on the discovery of the strange epidemic subjected to intense scrutiny. It was then found that a ritual involving the consuming of deceased relatives at mortuary feasts lay behind the phenomenon. It had no great antiquity but probably arose about the end of the 19th century, the first known case of kuru being in 1920. Adult women and children of both sexes were the prime sufferers, since they were the main participants at these cannibalistic feasts.

The report of an investigation published in Science for 25 April concludes that kuru was a disease attributable to prion infection and the first instance of a prion disease in humans. It is postulated that it arose from the eating of a tribesman suffering from Creutzfeld-Jakob disease.

Studies of the worldwide distribution of variants of the prion gene have given rise to the supposition that there may have been a tendency to cannibalism among ancient populations, an idea that has aroused controversy. It is known that individuals carrying two identical copies of the gene for the prion protein are more susceptible to Creutzfeld-Jakob disease than are others, and this may have applied to kuru in New Guinea. Among the Fore tribe the number of women carrying one copy of each variant was particularly high. And 23 of 30 women older than 50 and thus likely to have participated in cannibal feasts were heterozygotes for the gene, in contrast to the expected 15. Protection of the Fore against kuru may have been achieved by possession of one copy of each variant. Prion infections may have ravaged human populations in the distant past, mainly attributable to either eating tainted meats or possibly cannibalism.

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Change and decay

There has been much consternation among people who place value on the relics of human culture at the widescale looting and smuggling of antique works of art and articles of immense historical value from museums and art galleries lately, particularly in respect of the destruction that has accompanied the liberation of Iraq. How effective measures to recover and restore some of the historical treasures will prove is unknown, and there is much pessimism that a great deal of the world's heritage is gone for ever.

A rather different aspect of loss is discussed in Science for 11 April. When caves at Lascaux in France were discovered in 1940 and revealed wall paintings dating back some 15,000 years, there was enormous interest, and the caves attracted 1,000 visitors every day. However, in 1963 public access had to be forbidden because of the growth of green algae that were destroying the pigments of the paintings. This was a result of the introduction of water vapour by those visiting the caves, and it was hoped that a solution could be found to this unforeseen complication.

Treatment with formaldehyde was attempted, together with the installation of a air-conditioning system. For a time this measure seemed effective, but in 2001 it was found that a fungus, Fusarium solani, had appeared on the walls and floor of the caves.

The French culture ministry undertook a further study of the biology, chemistry, hydrology end climatology of the site. Growth of the fungus was retarded, but it was then found that the bacterium Pseudomonas fluorescens was thriving on the fungicide. Antibiotic treatment brought temporary improvement, but then new infestation took place, resistant to the previous treatments.

The effective long-term treatment has yet to be discovered and applied. Since the value of the cave art of Lascaux is immeasurable, this problem has raised tricky questions for those concerned with conservation.

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