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The Pharmaceutical Journal
Vol 271 No 7262 p197
16 August 2003

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Measles is becoming more contagious

The rate of spread of the measles virus in the United Kingdom is increasing, a study suggests.

Researchers used data from recent measles outbreaks in England and Wales to measure the reproductive number of the virus, which is the average number of new infections that an infected person causes.

They report that the reproductive number has risen from a value of 0.47 for the years 1995–98 to a value of 0.82 for the years from 1999–2002. The researchers point out that if the reproductive number exceeds a value of one, then the virus will not disappear after each outbreak, but may become a self-sustaining or endemic disease. “We are approaching the danger zone where measles could once again become an endemic disease in the United Kingdom. We are not yet there, but it may be going that way,” said Dr Vincent Jansen, one of the authors of the paper.

It is not known whether the drop in infant measles, mumps and rubella (MMR) vaccination uptake is responsible for this phenomenon, although the reproductive number is approximately proportional to the fraction of the population that is not immunised. “Of course the coincidence is suggestive of a causative connection, but we cannot draw this conclusion from our data,” Dr Jansen added (Science 2003;301:804).

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