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The Pharmaceutical Journal
Vol 271 No 7269 p474
4 October 2003

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Onlooker

Bigger, not better [more]
Change of diet [more]
Eat less, live longer [more]
Path to tranquillity [more]


Bigger, not better

There is an interesting discussion by Jared Diamond of Los Angeles in Nature for 21 August on the state of mind of some of the great ones of the earth when they marked their passage through history by building impressive monuments. He notes that often the most extravagant edifices were raised during the early days of a state’s history, before it reached the pinnacle of fame. Such structures, Diamond argues, were erected for propaganda purposes, to conceal the real lack of political competence and grandeur. And he hints that our current leaders may not be averse to similar vainglorious measures in their attempts to paint themselves larger than life to satisfy a starving ego.

Among the three great pyramids erected in the Egyptian desert at Giza the biggest is that of Khufu, with a base area of 5 hectares, height 146 metres, and weight 6 megatons. The pyramids erected by Khufu’s successors, Khafra and Menkaura, are much smaller. Yet Khufu in his day commanded no greater resources than his descendants. Indeed, later Egyptian dynasties had far more power, but left lesser monuments. They invested their resources in other ways, largely favouring trade and conquest. In this light the Great Pyramid itself must be looked upon as a great political and egoistic bluff.

In the same vein are the great rulers of Mexico and Peru. The great Pyramid of the Sun at Teotihuacan has a base area the same as that of the Great Pyramid but only half its height. Diamond speculates on the significance of the 5 hectares, which recurs several times in antiquity. Under the Aztec rulers, state revenues were invested in military or trading channels, as in later Egypt, rather than in impressive edifices. In Peru under the Moche, the Huaca de Sol pyramid also spanned 5 hectares, although its height was only one fifth that of Khufu’s monument. The later cultures of the New World favoured roads, irrigation canals and storehouses rather than pyramids.

One clue Diamond finds when looking at the strange giant statues of Easter Island. There the later statues are larger than the earlier. It seems, he thinks, that some civilisations were governed by rival clans rather than by a united government, and that this precluded the design of enormous buildings. Certainly among the Maya cultures the later, and larger, edifices were created by usurpers or else relatively weak kings, who sought through ostentation to magnify their doubtful power and boost their personal egos.

Diamond quotes an apt sentence from the work of Joyce Marcus on which he has based much of his argument, ‘Theory and practice in Mediterranean archaeology: Old World and New World perspectives’: “We should be as sceptical of ancient propaganda as we are when dealing with modern politicians.” The idea is well worth meditating upon.

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Change of diet

It appears from investigations carried out by Michael Richards of Bradford University and collaborators that at the onset of the Neolithic period in Britain some 5,000 years ago fishing as the main method of food seeking gave way abruptly to farming and the consumption of cultivated crops.

Writing in Nature for 25 September, the researchers say that carbon isotopes in bone collagen obtained from 164 early Neolithic skeletons between 4,500 and 5,200 years old and 19 skeletons from Mesolithic times dating back 9,000 years indicated that individuals living near the coasts took a predominantly marine diet, but by the time of the Neolithic culture just before 5,000 years ago both they and their inland cousins had taken to cultivating and eating cereals and roots.

The individuals sampled came from causewayed enclosures, chambered tombs, caves and other habitats. Inland dwellers were more prominently represented, but coastal individuals also showed signs of having changed their diet abruptly and of having turned their attention to domesticated plants and animals at the beginning of the Mesolithic.

Why this change should have occurred is not evident, unless it had something to do with rising sea levels at the time. In contrast, in other areas of Atlantic Europe, including southern Scandinavia and Brittany, economies dependent on marine products continued without alteration, which suggests that some factor operating locally was responsible for the dietary revolution in Britain.

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Eat less, live longer

It is known that reducing food intake increases the lifespan of many animal species. It is also recognised that there is no popular appeal in the suggestion that people might win an improved span, not only in quantity but in quality, if they ate less.

In Nature for 11 September, Toren Finkel of the United States National Institutes of Health in Maryland has commented on the quest for longevity since the days when Ponce de Léon sought the legendary fountain of youth in Florida. Today, he remarks, that same Florida is the goal of countless aged, and mostly overweight, retirees still seeking the elixir of youth.

To suggest to the ageing that eating less might benefit their health could never prove popular, but a drug designed to mimic the effects of caloric restriction would become a best-seller overnight. Enzymes called sirtuins act on mammalian cells to regulate programmed cell death and differentiation. They remove acetyl groups from specific target proteins by altering the intracellular concentration of nicotinamide adenine dinucleotide (NAD), and exist in oxidised and reduced states. In the oxidised state the sirtuin enzyme known as Sir2 has been shown to extend the life of yeast cells. The activity of this enzyme can be stimulated by polyphenols, including resveratrol, which abounds in red wine.

Plant polyphenols have been shown to possess potential health benefits, protecting against age-related maladies such as cancer, neurodegeneration and atherosclerosis, against which caloric restriction also brings protection. However, polyphenols exert a biphasic activity, depending on their concentration, and their value at present is problematical, and there is ample scope still for caloric restriction.

Yet, as Finkel remarks, Ponce de Léon, when he found the Florida springs, should have turned his attention to the many flowering plants surrounding them rather than concentrating upon the water which he believed would promote youth and vigour.

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Path to tranquillity

And yet it is always conducive to tranquility of mind to examine if possible oneself and one’s fortunes, but if that is not possible, to observe persons of inferior fortune and not, as most people do, compare with those who are superior

— Plutarch: ‘Moralia’ ( ca AD100).

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