The Pharmaceutical Journal
Vol 271 No 7275 p671
15 November 2003

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Tolerability of malaria prophylaxis

Although generally well tolerated, combined chloroquine and proguanil is associated with more adverse events than other recommended malaria prophylaxis regimens. In a study of 623 non-immune adults travelling to sub-Saharan Africa, chloroquine plus proguanil had the highest proportion of mild to moderate adverse events followed by mefloquine, doxycyline, and the combination of atovaquone and proguanil. The mefloquine and combined chloroquine and proguanil had the highest proportion of more severe events (BMJ 2003;327:1078).