The Pharmaceutical Journal
Vol 272 No 7289 p273
6 March 2004

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Neurology (www.neurology.org)

Statins and grapefruit

Patients treated with simvastatin and other statins metabolised by the isoenzyme CYP3A4 should be advised to avoid drinking grapefruit juice, say German researchers. They report a case of a woman with statin-associated muscle weakness triggered by grapefruit juice (Neurology 2004;62:670).