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PJ Online homeThe Pharmaceutical Journal
Vol 272 No 7299 p620
15 May 2004

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Onlooker

Mystery of the fairy rings in the desert more
Why alcohol is harder to control than tobacco more
How cell biology helps preserve art treasures more


Mystery of the fairy rings in the desert

In the past we have heard strange accounts of mysterious “corn circles” appearing for no apparent reason in our fields. Sometimes a deliberate hoax has been assumed, while for others no explanation has been forthcoming. Now a note from the University of Pretoria, published in New Scientist for 3 April, indicates that the mystery circle phenomenon may be more widely distributed than was hitherto thought. Discs of bare sandy soil 2m to 10m in diameter have been observed along the western coastal fringes of the desert of Namibia. They are characterised by a barren centre surrounded by a rich growth of tall grasses that stand in clear relief against the sparse local desert vegetation.

Three main hypotheses to account for these circles have been judged as inadmissible. The blame has been thrown on termite colonies, radioactivity in the underlying soils, and toxic debris from the milkbush plant Euphorbia damarana. But tests for local radioactivity have proved negative and soil from beneath the milkbush plant has been found perfectly capable of inducing flourishing growth in the grass Lolium multiflorum. The remaining hypothesis depends upon the possibility that termites might consume the entire seed production of grasses within the magic circle, thus denuding it of vegetation. Unfortunately for this theory, excavations two metres deep in the affected areas failed to reveal termites or their nests.

An alternative tentative proposal is that toxic deposits may by some means be laid down in the circles. This has been supported by the discovery that grasses grown experimentally in soil obtained from the affected areas have suffered prompt withering, whereas when planted in soil samples drawn from the periphery they have flourished. If indeed there are toxic elements involved their ultimate source is unknown. It is evidently not the milkbush.

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Why alcohol is harder to control than tobacco

Apparently the problems that alcohol poses to individuals and societies are beyond human control. Ethyl alcohol, which we usually mean when we talk of alcohol, has been misused by humans, and occasionally other animals, since the beginning of time to achieve extraordinary states of mind. However, its wide consumption as an accepted intoxicant is a growing menace to civilised societies.

It is intriguing to remember that the very word “alcohol” carries a confused network of derivations. Originally, according to the Oxford English Dictionary, it came from al-kohl, an Arabic word signifying a fine powder used to stain the eyelids, referring to powdered sulphides of antimony and lead. Today we tend to think of alcohols as liquids, although there are some, derived from fats, that are solids.

In Nature for 8 April, Helen Pearson reviews the mixed messages that we receive regarding alcohol and its relation to health. She points out that “alcohol and tobacco are the terrible twins of public health”: both are capable of increasing the risk of cancer and other life-threatening diseases, both are aggressively promoted by a powerful industry and favoured by politicians, and both are horribly addictive.

It seems strange that while tobacco, at least, has prompted stark health warnings in print and its slaves have to a great extent been shut out in public life from the company of their wiser fellows, there has been no such vilification of alcohol. And this is despite the warning of the World Health Organization that the harm caused by alcohol nearly equals that attending smoking.

The failure of public health campaigns to meet the challenge of alcohol may be attributed to its detrimental effects being less clear-cut than those of tobacco. There is even an argument abroad that moderate drinking of alcohol is beneficial in reducing the risk of heart attacks later in life. If such a doubtful benefit exists, it may well be limited to a small number of individuals. The cardiovascular gains are outbalanced by the likely losses in terms of cancers, liver cirrhosis and neuropsychological disorders. It is wiser to rely on increased exercise and improved diet than on a marginal benefit from alcohol.

Moreover, there is difficulty in calculating individual consumption of ethanol, since the alcoholic content of drinks varies widely from product to product and from country to country. Conflicting messages from health authorities, the media and the alcohol industry naturally confuse drinkers who encounter them. “Moderation” cannot be precisely defined. The highest disease rate attributable to alcoholism is seen in the former socialist countries of Eastern Europe and in Latin America — nations with a tradition of heavy drinking. But in rich developed countries the phenomenon of “binge drinking” by youngsters is presenting a growing problem.

We need stronger measures to curb alcohol consumption. These could include raising the minimum drinking age, reducing the number of outlets selling alcohol, restricting the hours when drinks may be sold and increasing prices. The benefit of such measures could be dramatic — and not just in terms of public health but also in reducing violent crime.

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How cell biology helps preserve art treasures

After my comments on chemical reactions producing strange phenomena in oil paintings (PJ, 24 April, p518), I was intrigued to read a report by Hannah Hoag in Nature for 29 April regarding another menace that museum curators may encounter: insects and fungi occasionally disfigure works of art, even some of recent origin, and chemical treatment may threaten their integrity.

Attacks on museum artefacts observed by Robert Koestler at the Metropolitan Museum of Art in New York led him to devise methods for dealing with fungi and moulds. He suspected that chemical treatments did more harm than good in many instances. For example, the fumigation of oil paintings with sulphuryl fluoride could change pigment colours or injure glosses. And, as a severe irritant, the agent poses a hazard to handlers.

Koestler devised a new way of defeating animal pests. He fumigated art works with argon after enclosing them in a bag with ferrous oxide to absorb any oxygen. When the oxygen concentration had fallen below 400ppm the bag was sealed and set aside for several weeks. The method was claimed to kill most insects and bacteria and some fungi without harming surfaces, fabrics or handlers.

Some fungal species are resistant to such treatment. Some Penicillium and Fusarium species can produce green or pink spotting on manuscripts and black stains on paintings and drawings. The black marks of melanin from fungal cell walls are particularly troublesome. Enzyme treatment may be possible, and ultraviolet irradiation could eradicate spores.

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