Prescription Products
Faslodex
 Composition: Fulvestrant 250mg in 5ml.
Presentation: Solution for injection in 5ml pre-filled syringe.
Action: Oestrogen receptor antagonist.
Indications: Treatment of postmenopausal women with oestrogen receptor-positive,
locally advanced or metastatic breast cancer for disease relapse on,
or after, adjuvant anti-oestrogen therapy or disease progression on therapy
with an anti-oestrogen.
Dosage: 250mg at monthly intervals.
Precautions: Use with caution in patients with mild to moderate hepatic
impairment, severe renal impairment, bleeding diatheses, thrombocytopenia
or those taking anticoagulant treatment. See SPC.
Contraindications: Pregnancy or breast-feeding, severe hepatic impairment,
hypersensitivty to the drug or excipients.
Side effects: Include hot flushes, nausea and injection site reactions.
Net price: One pre-filled syringe £348.27.
Contact details: Astra Zeneca UK, Horizon Place, 600 Capability Green,
Luton, Bedfordshire LU1 3LU (tel 01582 836 000).
Somavert
Composition: Pegvisomant
Presentation: Powder and solvent for solution for injection.
Action: Growth hormone receptor antagonist.
Indications: Treatment of patients with acromegaly who have had an inadequate
response to surgery and/or radiation therapy and in whom an appropriate
medical treatment with somatostatin analogues did not normalise IGF-I
concentrations or was not tolerated.
Dosage: A loading dose of 80mg should be administered subcutaneously
under medical supervision. A subcutaneous injection of Somavert 10mg
reconstituted in 1ml of water for injections should then be administered
once daily. Dose adjustments should be based on serum IGF-I levels. Maximum
dose should not exceed 30mg per day. See SPC.
Precautions: Treatment should be initiated under the supervision of a
physician experienced in the treatment of acromegaly. Serum IGF-I concentrations
should be measured every four to six weeks.
Side effects: Include injection site reactions, sweating, headache and
asthenia.
Net price: 30 vials, 10mg £1,500, 15mg £2,250, 20mg £3,000.
One vial, 20mg £100.
This product is for home delivery and will be distributed on behalf of
Pfizer by Healthcare at Home (tel 0870 366 4640).
Contact details: Pfizer, Walton Oaks, Dorking Road, Tadworth, Surrey
KT20 7NS (tel 01304 616161).
Hydroxocobalamin
 Hydroxocobalamin solution for injection 1mg in 1ml is now available from
Auden McKenzie; net price, 5 ampoules £12.31.
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Carvedilol tablets
Carvedilol tablets are now available from Pliva Pharma in packs of 28; net
price, 3.125mg £8.13, 6.25mg £9.03, 12.5mg £10.04. Carvedilol
tablets 3.125mg are also available from Alpharma; net price, 28 £8.14.
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