Prescription Products
Dukoral
 Composition: Each 3ml dose contains1x1011 killed whole Vibrio
cholerae 01 bacteria (Inaba and Ogawa serotypes and of El Tor and classical biotypes,
and the recombinant cholera toxin B subunit (rCTB), 1mg.
Presentation: 3ml vial of suspension and sachet of effervescent granules
(sodium hydrogen carbonate) for oral suspension.
Class: Oral cholera vaccine.
Indications: Active immunisation against disease caused by V cholerae serogroup 01 in adults and children who will be visiting endemic or epidemic
areas.
Dosage: Adults and children over six years: two doses administered at
intervals of one to six weeks. Children aged two to six years should
receive three doses. Immunisation should be completed at least a week
prior to potential exposure to V cholerae 01. A single booster dose can
be given after two years for adults and children over six, and after
six months for children aged two to six years.
Major cautions: Administration should be postponed for subjects suffering
from acute gastrointestinal illness or acute febrile illness. Food and
drink should be avoided one hour before and one hour after vaccination.
Caution should be taken in subjects hypersensitive to formaldehyde as
trace amounts may be present in the product.
Side effects: uncommon,include abdominal discomfort, diarrhoea, headache.
Net price: 2 doses £23.42,
20 doses £234.20.
Contact details: Chiron Vaccines Evans, Gaskill Road, Speke, Liverpool
L24 9GR. Tel 08457 451 500.
Paxene
Paxene (paclitaxel) 6mg/ml concentrate for solution for infusion is now
available from Mayne Pharma; net price, 1 vial, 30mg £112.20,
100mg £374, 150mg £561, 300mg £1,122.
Tramacet tablets
Tramacet (tramadol hydrochloride 37.5mg and paracetamol 325mg) tablets
have been launched by Janssen-Cilag; net price, 60 £10.60.
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