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PJ Online homeThe Pharmaceutical Journal
Vol 273 No 7307 p45
10 July 2004

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Soy does not improve effects of menopause

Women taking soy protein and isoflavones to counteract the effects of the menopause may be wasting their time. A study examining the effect of a soy supplement has found that it did not improve cognitive function, bone mineral density or plasma lipid levels.

Researchers in the Netherlands compared use of a soy protein supplement with placebo in 202 healthy postmenopausal women aged between 60 and 75 years. Participants received either 25.6g of soy protein containing 99mg isoflavones or total milk protein as a powder daily for 12 months.

After a year, they found no difference between the groups in terms of cognitive function, bone mineral density or plasma lipids. Although one of 13 measurements of bone mineral density was improved in the soy group, the authors comment that because it was only one among 13 comparisons it could be a chance finding.

The lack of effect contrasts with some earlier studies. The authors point to differences that might explain this, such as the other studies being conducted in animals, men or younger populations, or having a small number of trial participants. One difference they say requires further research is the influence of the timing of supplementation since women who are recently menopausal may benefit more from soy protein supplements than women in later stages of the menopause (JAMA 2004;292:65).


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