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Vol 273 No 7310 p137
31 July 2004

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Pharmacists called on to tackle oral methotrexate safety issues

Input from pharmacists is key to implementing the latest patient safety alert — on the risks associated with use of oral methotrexate — issued by the National Patient Safety Agency.

The alert sets out action points to combat risks associated with the drug. NHS trusts and primary care organisations in England and Wales are expected to implement the recommendations by March 2005.

Local drug and therapeutics committees are asked by the NPSA to review shared care arrangements for prescribing and monitoring oral methotrexate. Having done this, they should then ensure that patient information (supplied in template form by the NPSA as part of the alert) is issued to all patients before and during treatment. Patient-held monitoring and dosage records should also be provided to all patients taking methotrexate.

Pharmacists are requested to assess patients’ needs in terms of packaging, labelling and patient information.

Additional action required includes upgrades to prescribing and pharmacy dispensing IT systems and a review of purchasing procedures for methotrexate.

Wendy Harris, senior pharmacist at the NPSA, said: “We’ve had to tackle this complex problem at a number of levels, and have combined forces with industry, and involved patients, clinicians and pharmacists.”

The alert and supporting resource material can be downloaded from the NPSA website. Hard copies are available from the Department of Health order line (tel 08701 555455, quoting reference number PSA03).


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