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PJ Online homeThe Pharmaceutical Journal
Vol 273 No 7314 p279
28 August 2004

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Review hypertension management, says NICE

Drug recommendations

The new NICE guideline recommends that drug therapy should be offered to patients with persistent high blood pressure of 160/100mmHg or more and to those at raised cardiovascular risk with persistent blood pressure of more than 140/90mmHg.

It states that a low-dose thiazide-type diuretic should be used first line, with a beta-blocker as second line unless the patient has an increased risk of new onset diabetes, in which case an angiotensin converting enzyme inhibitor should be added.

A dihydropyridine calcium-channel blocker is recommended as third line.

Local health communities are being asked to review their management of hypertension against a new guideline issued this week by the National Institute for Clinical Excellence and the Newcastle Guideline Development and Research Unit.

The priorities for implementation focus on measuring blood pressure, assessing cardiovascular risk, pharmacological and lifestyle interventions, and continuing treatment.

Assessment of cardiovascular risk in patients with persistent raised blood pressure is a key theme and will help identify diabetes, evidence of hypertensive damage to the heart and kidneys and secondary causes of hypertension.

The guideline also recommends that lifestyle advice should be offered initially and then periodically to patients undergoing treatment for hypertension.

If a patient has well-controlled blood pressure and is at low cardiovascular risk, the guideline states that they should be offered a trial reduction or withdrawal of therapy with appropriate lifestyle guidance and review.

Mohammed Ahmed, prescribing pharmacist at Doncaster West Primary Care Trust, told The Journal: “Supplementary prescribers need to grasp the guidelines because these are guidelines against which they will be judged. I will certainly deviate from these on occasions but only when evidence permits me and in discussion with the independent prescriber.”

Graham MacGregor, chairman of the Blood Pressure Association, voiced some concerns about the recommendations. “The guidelines assume a model patient scenario of someone who has hypertension alone, and do not reflect the range of treatment options which may be more beneficial to patients presenting with pre-existing conditions.” He pointed out that the British Hypertension Society’s guidelines published earlier this year (PJ, 20 March, p342) differentiate between age and ethnic groups and provide a range of treatment options. He said: “The association is concerned that the presence of two guidelines may lead to confusion both for patients and health care professionals, and particularly that there are differences in the treatment pathway.”

The new guideline can be accessed here

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