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PJ Online homeThe Pharmaceutical Journal
Vol 273 No 7319 p456
2 October 2004

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Cognitive behaviour therapy more effective than drug treatment in chronic sleep onset insomnia

Cognitive behaviour therapy (CBT) is more effective than zolpidem in the treatment of insomnia and should be considered as first line treatment.

So says Gregg Jacobs, assistant professor of psychiatry at Harvard medical school and specialist at a sleep disorders centre. In a trial, his team investigated 63 young and middle-aged adults with chronic sleep onset insomnia.

Patients were randomised to CBT, pharmacotherapy with zolpidem, combination therapy and placebo.

The outcome measures studied included sleep onset latency, sleep efficiency, total sleep time and daytime functioning. In most measures, CBT was the most effective intervention. It produced the greatest changes in sleep onset latency and sleep efficiency, yielded the largest number of “normal” sleepers after treatment and continued to maintain therapeutic gains at long-term follow up (to one year).

Combination therapy produced no advantage over CBT alone. Drug treatment produced only moderate improvements during therapy, with its effects receding after discontinuation.

“Increased recognition of the efficacy of CBT and more widespread recommendations for its use could improve the quality of life of a large number of patients with insomnia,” the study’s authors conclude (Archives of Internal Medicine 2004;164: 1888).

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