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PJ Online homeThe Pharmaceutical Journal
Vol 273 No 7328 p806
4 December 2004

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Smoking and salt increase GORD

Smoking and a high intake of salt are associated with a greater risk of gastro-oesophageal reflux symptoms, a recent study has shown.

Researchers at the Karolinska hospital in Sweden carried out a population-based study involving 3,153 Norwegian patients with gastro-oesophageal reflux disease (GORD) and 40,210 people without symptoms as controls. They calculated the risk of GORD symptoms in relation to several lifestyle risk factors: smoking, coffee and tea consumption, salt intake, alcohol consumption, fibre intake and physical exercise.

The researchers found that the risk of reflux was increased by 50 per cent in people who consume salted food at least three times per week compared with those who never ate salted food. The risk of reflux symptoms increased by 70 per cent in people who always added salt to their meals.

Long-term daily smoking (20 years or more) increased the risk of reflux by 70 per cent compared with people who had smoked for less than one year.

The study also showed that eating bread high in dietary fibre and taking regular exercise can protect against acid reflux symptoms. Symptoms were reduced by 50 per cent in people eating predominantly high-fibre bread and by 50 per cent in people who exercised at least once a week.

Coffee consumption also appeared to reduce the risk of GORD by up to 40 per cent, although the researchers point out that the results may have been skewed because many people with reflux symptoms avoid drinking coffee. Drinking tea and alcohol had no effect on the risk of GORD symptoms, irrespective of the quantities consumed (Gut 2004;53:1730).

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