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PJ Online homeThe Pharmaceutical Journal
Vol 274 No 7334 p102
29 January 2005

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Mycophenolate endorsed for transplant rejection in Scotland

Mycophenolate sodium (Myfortic) can be used within the NHS in Scotland for the prevention of acute transplant rejection, the Scottish Medicines Consortium has announced.

In guidance issued earlier this month, the SMC recommended that mycophenolate be used in combination with ciclosporin and corticosteroids in adult patients receiving kidney transplants.

A further four products, three used in the treatment of epilepsy, were accepted for restricted use by the SMC.

Pregabalin (Lyrica) is endorsed for use as adjunctive therapy in adults with partial seizures with or without secondary generalisation. The SMC advises that it should be used principally to treat patients who have not benefited from other antiepileptics such as carbamazepine or sodium valproate, or for whom these drugs are not suitable. Levetiracetam (Keppra) 750mg tablets and 100mg/ml oral solution are recommended as additional dosage forms also for use as adjunctive therapy in the treatment of partial seizures with or without secondary generalisation.

Caspofungin (Cancidas) is also recommended for restricted use — to treat presumed fungal infections in febrile, neutropenic adult patients who are under the care of a fungal disease specialist.

Two drugs failed to receive an endorsement from the SMC: nicotinic acid modified release tablets (Niaspan) is not recommended either as monotherapy or in combination with statins for the treatment of dyslipidaemia and primary hypercholesterolaemia, and efalizumab (Raptiva) is not recommended for treatment of adults with moderate to severe chronic plaque psoriasis.

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