The Pharmaceutical Journal
Vol 274 No 7337 p200
19 February 2005

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COX-2s raise blood pressure

Selective cyclo-oxygenase-2 inhibitors raise blood pressure more than conventional non-steroidal anti-inflammatory drugs, say researchers who reviewed data from 19 randomised controlled trials. They also found that rofecoxib was associated with a higher risk of clinically important elevations in blood pressure than celecoxib (Celebrex).

The study is published online in Archives of Internal Medicine.