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Vol 274 No 7338 p226
26 February 2005

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Pharmacist-led heart clinics effective

Pharmacists used dose titration protocols

Pharmacists used dose titration protocols

Cardiac clinics led by pharmacists can improve the proportion of patients taking the recommended treatment and reduce symptoms of heart failure. So say researchers who report results from a pharmacist-led heart failure clinic in London (European Journal of Heart Failure 2005;7:405).

Over a three-year period, 265 patients with heart failure were referred to clinics set up in Newham Healthcare Trust and Barts and The London NHS Trust. The clinics were led by a cardiac pharmacist and staffed by specialist nurses. Management guidelines for the initiation of treatment via patient group directions were established, and the clinics were supervised by a consultant cardiologist. Protocols were also established for the up-titration of treatment and the measurement of biochemical markers.

The researchers report that out of the 234 patients that had at least one follow-up visit, 127 patients (57 per cent) were either not receiving a key therapeutic agent or were missing a recommended drug on presentation at the clinic. This was reduced to 25 patients (11 per cent) after a two-year follow-up. Significant up-titration of dose was seen for patients on beta-blockers and angiotensin-converting enzyme inhibitors or angiotensin receptor blockers. These treatment interventions were associated with reductions in heart rate and systolic blood pressure.

The researchers report a reduction in the proportion of patients with moderate or severe heart failure, as classified by the New York Heart Association, and say that no deterioration of renal function or adverse effects on electrolytes were seen.

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