The Pharmaceutical Journal
Vol 274 No 7353 p703
11 June 2005

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Gene therapy for arthritis

A therapeutic gene can be safely transferred into human rheumatoid joints, say researchers.

They introduced a gene encoding the IL-1 receptor antagonist into synovial cells of nine women with rheumatoid arthritis, using an inactivated retrovirus. The cells expressing the transduced gene produced less inflammatory cytokines than cells not treated (PNAS 2005;102:8698).