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Vol 274 No 7355 p784
25 June 2005

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Dietary calcium and vitamin D may stop PMS

High intake of dietary calcium and vitamin D may reduce the risk of developing premenstrual syndrome, according to researchers in the US.

Elizabeth Bertone-Johnson, department of public health, University of Massachusetts, and colleagues conducted a case control study of nurses aged 27 to 44 years old, who were free from PMS at baseline (1991). Over 10 years of follow up 1,057 women developed PMS and 1,968 reported no diagnosis of PMS and no or minimal menstrual symptoms. Intake of dietary and supplemental calcium and vitamin D was measured via a postal questionnaire in 1991, 1995 and 1999.

Results show that intake of dietary calcium is inversely related to PMS. Women with the highest intake (median 1,283mg per day) had a relative risk of 0.70 compared with those with a low intake (median 529mg per day) (P=0.02). Similarly, women with a high intake of dietary vitamin D (median 706IU per day) had a lower risk of developing PMS compared with those with a low intake (median 112IU per day) (P=0.01).

The researchers found no association between calcium and vitamin D supplements and risk of PMS but say the proportion of women in the study taking calcium supplements was small.

“Our findings, together with those from several small randomised trials that found calcium supplements to be effective in treating PMS, suggest a high intake of calcium and vitamin D may reduce the risk of PMS. Given that calcium and vitamin D may also reduce the risk of osteoporosis and some cancers, clinicians may consider recommending these nutrients even for younger women,” the authors conclude (Archives of Internal Medicine 2005;165:1246).

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