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PJ Online homeThe Pharmaceutical Journal
Vol 275 No 7366 p303
10 September 2005

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Drug-eluting stents should be limited to high risk patients

Drug-eluting stents are more cost-effective when limited to patients in high-risk groups than when used in all patients, a study has shown (Lancet 2005;366:921).

The study of 826 patients treated with angioplasty and stenting found that the higher costs of drug-eluting stents were not compensated for by lower follow-up costs.

However, subgroup analysis showed that drug-eluting stents were more cost-effective for elderly patients in specific high-risk groups.

The authors say that use of drug-eluting stents was more cost effective, or even cost saving, in subgroups of high-risk elderly patients with three-vessel disease or who required treatment in multiple segments, long segments or small vessels.

“Therefore, the use of drug-eluting stents could be restricted to certain high-risk patient subgroups … at least until the prices of drug-eluting stents are reduced,” they conclude.

The National Institute for Health and Clinical Excellence currently recommends the use of sirolimus-eluting or paclitaxel-eluting stents for patients with coronary artery disease in whom the target artery is less than 3mm in internal diameter or the lesion is longer than 15mm.

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