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PJ Online homeThe Pharmaceutical Journal
Vol 275 No 7371 p475
15 October 2005

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Self-management an option for oral anticoagulation

Warfarin-treated patients

Warfarin-treated patients can monitor their INR safely but are reluctant to do so

Self-management for oral anticoagulation is as effective as routine care, if patients are appropriately trained, a study published online at BMJ Online First (PDF 100K) on 10 October suggests.

Point-of-care devices were used by 242 patients receiving warfarin to measure their international normalised ratio twice a week. Patients then used a simple chart to adjust their dose. The control group of 275 patients received routine care in UK oral anticoagulation clinics. There was no significant difference between the two groups in the proportion of time spent within the therapeutic range, but self-managed patients with initial poor control showed a greater improvement in control.

In the self-management group there was a 20 per cent improvement in INR for those whose target was 3.5 (mainly those with mechanical heart valves) and a 15 per cent improvement for those with a target of 2.5. For the routine care patients, there was an improvement of 3–5 per cent for the two groups.

However, demand from patients for self management was limited — a quarter of patients who accepted the invitation to self-manage did not complete the training and a fifth of those who did complete training withdrew prematurely — although the researchers believe their findings may change this.

“Now that self-management for anticoagulation has been shown to be as safe and effective as routine care, it would be valid to test whether this reassurance alters patients’ (and health professionals’) equipoise in considering whether to accept self management in this context,” they conclude.

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