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PJ Online homeThe Pharmaceutical Journal
Vol 275 No 7376 p622
19 November 2005

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Cancer-related anaemia is undertreated

Cancer-related anaemia is seriously undertreated, with less than one-third of anaemic patients receiving treatment, according to a study presented at the European Cancer Conference in Paris earlier this month.

The European Cancer Anaemia Study included more than 15,000 cancer patients, who were not receiving chemotherapy at the time of enrolment. Results show that 32 per cent were anaemic — 24 per cent had haemoglobin (Hb) levels between 10.0 and 11.9g/dL and 8 per cent had Hb levels lower than 10.0g/dL. However, only 31 per cent of these received any treatment for anaemia.

Most anaemia was seen in patients with persistent or recurrent disease (38 per cent); 30 per cent of newly diagnosed patients and 25 per cent of patients in remission were also anaemic. Poor performance scores correlated positively with lower haemoglobin levels.

A survey of 250 patients with cancer from five European countries also showed that more than half of those with cancer-related anaemia were not receiving recommended therapy.

Overall results showed that 58 per cent of patients with anaemia were not receiving erythropoietin, the treatment recommended by the European standards for anaemia care. In the UK, 63 per cent of patients reported receiving no treatment of any kind for extreme fatigue or anaemia and only 5 per cent were treated with erythropoietin — much lower than in other countries.

Paul Corns, consultant oncologist, Bristol Haematology and Oncology Centre, warned: “Anaemia is greatly underdiagnosed and undertreated in patients with cancer, even though its treatment could dramatically improve quality of life and functional capacity.” He considered that the problem was similar to that seen 10 years ago with nausea and vomiting associated with cancer treatment. That used to be considered inevitable but is now treated routinely.

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