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Vol 275 No 7381 p767
24 December 2005

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New guidelines set lower cholesterol targets

New clinical guidelines predicted to reduce the number of people dying each year from cardiovascular disease have been published in a supplement to the December issue of Heart.

The guidelines replace the Joint British Societies Guidelines on Coronary Prevention in Clinical Practice (JBS 1) which were published in 1998.

The new guidelines widen the criteria for prevention of heart disease and stroke in primary care and for the first time target patients with cardiovascular disease (CVD). The previous guidelines applied only to those patients with coronary heart disease (CHD).

They also, for the first time, recommend that all at-risk patients, as well as those with established disease, have access to the full range of treatment — including medication.

Although the blood pressure targets in the new guidelines (JBS 2) are the same as JBS 1, they recommend a lower target level for cholesterol. The new guidelines recommend a total cholesterol target of 4.0mmol/L (compared with 5.0mmol/L under JBS 1) and a target for low-density lipoprotein cholesterol of 2.0 mmol/L (compared with less than 3mmol/L under JBS 1), or a 25 per cent reduction in total cholesterol and a 30 per cent reduction in LDL cholesterol, whichever achieves the lowest absolute value.

The guidelines also recommend that everybody who has been assessed as having a CVD risk of more than 20 per cent over the next 10 years should be receiving appropriate drug treatment.

Commenting on the guidelines, chairman of the Primary Care Cardiovascular Society, GP Terry McCormack, said:“If the targets are followed, JBS 2 will lead to more lives being saved and a considerable reduction in incapacitating CV events.”

The guidelines, from the British Cardiac Society, the British Hypertension Society, Diabetes UK, Heart UK, the Primary Care Cardiovascular Society and the Stroke Association, recommend CVD screening for:

All adults aged 40 years and older, with no history of heart attack, stroke, or diabetes, and not already being treated for high blood pressure or cholesterol

All adults under 40 years with a family history of developing hardened and narrowed arteries earlier than expected (under 65 years for women and under 55 years for men).

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