Hope for narcoleptics to regain muscle tone
Narcoleptics can now be treated to reduce the loss of muscle tone that narcolepsy induces.
The new treatment (Xyrem) has as its active substance the sodium salt
of gamma hydroxybutyrate (sodium oxybate). Gamma hydroxybutyrate is a
CNS depressant with well known abuse potential, so the summary of product
characteristics advises evaluating patients for a history of drug abuse
and following them closely. The recommended starting dose is 2.25g (4.5ml)
twice a day.
The dose should be adjusted up or down in increments of 0.75g per dose
up to a maximum of 4.5g twice a day to achieve best effect and tolerability.
A minimum of two weeks is recommended between dosage increments.
Xyrem should be taken orally upon getting into bed and again between
2.5 and 4 hours later — the SPC recommends that both doses of Xyrem
be made up at the same time (on retiring to bed).
Notice-board p200 |
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