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The Pharmaceutical Journal
Vol 276 No 7391 p296
11 March 2006

Books

Revised edition of pharmacology hand book requires more work

The hands-on guide to clinical pharmacology’ (2nd edition), by Christopher Tofield, Alexander Milson and Sukhdev Chatu. Pp viii+200. Price £12.95. Oxford: Blackwell Publishing; 2005. ISBN 1 4051 2015 0


This paperback, pocket-sized book is a revised second edition and consists of a set of clinical pharmacology revision notes. The book is aimed at medical students and junior doctors. The authors have chosen what they believe are the most common medicines used in secondary health care practice. It was originally written by three medical students (now in practice) from examination revision notes. This book is claimed to be a study aid and a user-friendly reference on the wards.

Doses of medicines have been omitted, since they are not considered relevant to students, and the authors have included only the interactions, adverse effects and contraindications that they think are important. The authors suggest consulting the British National Formulary for more information. Organised into a directory of 127 medicines (compared with 105 five years ago) in 183 pages, using a body-systems approach, each section is prefixed with a set of management guidelines. It is strange that in this age of evidence based information there are no national guidelines mentioned or any other evidence-based source listed.

A reasonable attempt has been made to cover most therapeutic areas and only four topics listed in the BNF are not covered in this book, ie, malignant disease, nutrition and blood, the eye and the ear, nose and throat. It would have been useful if the order of presented sections matched the BNF. There are also no illustrations to support some of the complex pharmacological explanations. The content seems to be lacking in some areas:

  • The low molecular weight heparins are hardly mentioned and there is nothing said about the use of heparins in reduced renal function
  • There is no mention of tiotropium
  • It is not helpful to have discontinued medicines (from 2001) like reproterol and tulobuterol still listed
  • Administration of vancomycin has little data listed but is a common problem in secondary care and the spelling of this drug seems to vary in the text
  • The Heaf test is no longer available
  • Bendrofluazide has not been changed to the current name (bendroflumethazide) when other drugs in the text have
  • There is a lack of information on Cox-2 inhibitors and their problems, with rofecoxib being indexed to p100 but there is no mention of this on p100

With all these discrepancies, this revision is not complete and requires more work.

On a more positive note the text is easy to read in bullet form and it is a nice idea to show the value of mnemonics to memorise lists of medicines.

As a study aid in clinical pharmacology this book is limited but may be of use to someone. As a practical reference on the wards I would not recommend its use. I would advise the use of the BNF.


Andrzej Kostrzewski
Senior principal pharmacist at St Thomas’s Hospital Teaching Unit, London

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