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PJ Online homeThe Pharmaceutical Journal
Vol 276 No 7396 p452
15 April 2006

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Onlooker

Pioneer of natural products chemistry more
How multinational tobacco companies maintain a disturbing influence more
Enthusiasm for giant dams — is it shortsighted and hazardous? more


Pioneer of natural products chemistry

European yewLittle seems to have been reported until recently regarding a French pharmacist who made many investigations into derivatives from natural products during the second half of the 20th century. However, an obituary notice published in Nature for 16 March throws light upon Pierre Potier, who died on 3 February 2006. Potier was active in the study of developing anticancer drugs and in encouraging communication between the private and public sectors.

Potier was the son of a watchmaker, born in 1934 in Bois-Colombes, a northern suburb of Paris. He chose to study pharmacy and graduated in the profession in 1957 at the Paris Faculty of Pharmacy. His first venture into the field of natural drug products was in the Institut de Chimie des Substances Naturelles at Gif-sur-Yvette, where he studies biosynthesis in plants and animals. From 1974 to 2000 he headed the institute.

In 1965 Potier devised a modification of the Polonovski reaction by which plant alkaloids are N-demethylated or N-deacylated. This made possible the biomimetic synthesis of many natural products. He invented the tubulin test and applied it to testing anticancer compounds. It enabled Potier and his colleagues to develop vinorelbine, derived from vinca alkaloids, and used to counteract lung and breast cancer.

Potier’s main contributions came between 1979 and 1994, and involved products from the yew tree. He synthesised docetaxel, using extracts from the needles of the European yew, and paclitaxel, a compound previously obtained at great expense from the bark of the Pacific yew. He also worked on diabetes remedies.

He was the author of more than 400 publications and held several patents. In addition, he held many academic appointments and was awarded many prizes. As his biographer, Francois Chast notes, Pierre Potier had a great sense of humour. He was generous and showed a deep appreciation of literature and history. He has been seen as a worthy successor to the French physiologist Claude Bernard (1813–78).

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How multinational tobacco companies maintain a disturbing influence

“A sovereign remedy to all diseases” — such was the praise afforded by Robert Burton to tobacco in his 17th century “Anatomy of melancholy” (1621). However, he went on to say that “as it is commonly abused by most men, which take it as tinkers do ale, ’tis a plague and mischief, a violent purger of goods, lands, health, hellish, devilish, and damned tobacco, the ruin and overthrow of body and soul”.

This divergent evaluation seems to persist to a great extent even today, when we have considerable evidence of the harm wreaked by tobacco. Yet, as an editorial comment by two experts from the University of California in the 11 February issue of the BMJ points out with acerbity, “The multinational cigarette companies act as a vector that spreads disease and death throughout the world”. The comment goes on to remark that this is because the tobacco industry uses its wealth to influence politicians to create a favourable environment to promote smoking. This is strong talk, but it is true. Tobacco and alcohol between them must take a huge responsibility for human sickness.

In responding to the tobacco menace, the authors of the comment observe that by January 2006, 121 countries had ratified the World Health Organization’s Framework Convention on Tobacco Control, but the industry has increasingly designed strategies to prevent meaningful control of the drug. When the government of Uzbekistan banned tobacco advertising and created smoke-free public areas, the ministry of health was persuaded by a tobacco company to overrule the decision and limit restriction to health care facilities, kindergartens, schools and other institutions for children. This move not only encouraged smoking in Uzbekistan but set a precedent for control policies in central Asian countries of the former Soviet Union.

In California the tobacco companies formed an alliance with the Californian Medical Association and added difficulties to the situation. The same strategy was used in Mexico in 2004. Warning labels were weakened. For those striving for a healthier tobacco-free society these developments are disturbing.

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Enthusiasm for giant dams — is it shortsighted and hazardous?

A special report in Nature for 23 March draws attention to the current craze for building massive dams across rivers in Africa, and outlines some of the possible undesirable results. a dozen such projects are under way across Africa with the help of Chinese money and expertise. Among them is the Merowe dam on the Nile north of Khartoum, a billion-dollar project that will more than double the amount of electricity that Sudan can produce.

Scientists and environmentalists who have made a study of the Merowe dam argue that poor local people will suffer because the precautions appropriate to the venture are not being observed. Inadequate thought has been given to the environmental and social consequences of flooding hundreds of square kilometres of countryside, a criticism that has also been levelled at other African ventures involving Chinese investments.

Previous projects in China, India, North America and elsewhere have resulted in serious downstream erosion from the removal of sediments, and resettled people have suffered a decline in their quality of life. The Merowe construction involves the building of a wall 7km long and 65m high to trap more than 10 million cubic metres of water. The land occupied by 10,000 families will be affected, necessitating four resettlement schemes. The accumulation of sediments behind the dam will affect farmers downstream who at present depend upon nutrients in sediments to fertilise fields during the annual floods. The water column in front of the dam will be partly anoxic and if passed through turbines and released could harm aquatic life further downstream as well.

Similar problems are anticipated from other Chinese-designed dams. It seems that the commercial firms involved in the contracts do not worry over such complications. Meanwhile the projects are being hurried through at breakneck speed.

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