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Vol 277 No 7420 p385
30 September 2006

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Variations in use of NICE-approved drugs reducing

Variations across England in access to cancer drugs approved by the National Institute for Health and Clinical Excellence are reducing, according to a report from national cancer director, Mike Richards, published last week. The report makes several recommendations, many of which cancer network pharmacists could get involved in.

The report follows on from a baseline review, conducted between July and December 2003, which showed that, although overall use of cancer drugs generally increased after a positive NICE appraisal, considerable variation in use of the drugs remained between cancer networks.

The latest review, conducted between January and June 2005, shows that this variation in use of all NICE-approved cancer drugs has reduced. It also shows a median increase in uptake of cancer drugs following positive NICE guidance of 47 per cent, ranging from 11 per cent for vinorelbine and fludarabine to 120 per cent for temozolomide.

The review looks at all 16 cancer drugs appraised by NICE (15 of which received a positive appraisal) plus four standard cancer drugs as comparators.

The report recommends that cancer networks should plan ahead and regularly monitor uptake of NICE-approved drugs to ensure that the level of variation is reduced as much as possible. A capacity planning tool developed by the Association of the British Pharmaceutical Industry, the Department of Health Cancer Action Team and the NHS Cancer Services Collaborative will be ready for roll out to cancer networks next month. Central money to support the purchase of chemotherapy e-prescribing systems has been made available and networks should capitalise on this, it adds.

David Thomson, chairman of the Cancer Network Pharmacists Forum and lead pharmacist for Yorkshire Cancer Network, told The Journal that the recommendations in the report highlight some key areas that pharmacists could get involved in, including monitoring the NICE website, using the capacity planning tool, e-prescribing and monitoring uptake of drugs.

“This is an opportunity to tell cancer networks that they need to think about employing a pharmacist,” he said. Currently, just under half of cancer networks include a pharmacist.

Libby Hardy, lead pharmacist for Peninsula Cancer Network, said that the report shows that action plans provided by those networks in which drug use was found to be low in the first review have been successful. “In many situations the under-usage was as a result of capacity limitations within the acute trusts,” she said. However, she added that there are some limitations in the accuracy of the data in the latest report, and for that reason, caution should be exercised when comparing the usage directly between cancer networks.

“Once [the e-prescribing systems for chemotherapy] are operational, cancer networks using e-prescribing should be able to provide accurate data on the use of all chemotherapy drugs. They should also be able to link the treatment with the stage and type of tumour,” said Dr Hardy.

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