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PJ Online homeThe Pharmaceutical Journal
Vol 277 No 7427 p597
18 November 2006

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Far wider population would benefit from statin treatment

Lifetime statin treatment would be cost effective in a far wider population than that covered by current guidelines, a study published on BMJ Online First on 15 November 2006 suggests.

The researchers developed a model to estimate lifetime risk of vascular events, and costs of treatment and hospital admissions, for 20,536 men and women across the UK. Treatment with statins was cost saving, or cost less than £2,500 per life year gained, in people aged 35–85 years who had a five-year risk of a major vascular event of only 5 per cent at the start of treatment. “Statin therapy should be considered routinely for people across a wider age range and at lower risk of vascular disease than is currently the case,” they argue.

Alastair Gray, professor of health economics at Oxford University and one of the authors of the paper, told The Journal that a similar logic could be applied to extending eligibility for over-the-counter statins. “People who are at a lower level of risk than those currently eligible should be able to buy simvastatin OTC,” he said. However, he added: “Since simvastatin is available generically and we have shown that it is cost-effective or cost-saving for people with a 5 per cent five-year risk of a major vascular event, it might be better if it was made available for those people on the NHS.”

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