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PJ Online homeThe Pharmaceutical Journal
Vol 278 No 7446 p389
7 April 2007

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E-prescribing would help hospitals control infection

Dr Kari Lounatmaa/Science Photo Library

Clostridium difficile

Clostridium difficile likely to thrive without electronic prescribing

Hospitals will continue to struggle to control outbreaks of infectious diseases unless they introduce electronic prescribing, says the Health Protection Agency.

“We’ve got to get some form of computerised monitoring of our prescribing,” said Andrew Pearson, deputy director of the HPA’s centre for infections. “The problem is that very few hospitals in the UK have electronic prescribing — just three.”

Dr Pearson was speaking at a conference on health care-associated infections in Lon-don last week. He said it was crucial that patients received the correct treatment but the evidence suggests that often they do not. Without knowledge of what has been prescribed, when and at what dose, infections like Clostridium difficile will continue to thrive, he added.

In the US, where electronic prescribing in hospitals is well established, the University of Maryland uses computer software to monitor antibiotic use at different hospitals, said Dr Pearson. The software flags up prescribing errors so patients’ drugs can be corrected. In a trial comparing patients whose errors were corrected with those that were not, the difference in death rate was 4.5 per cent at three months so the trial was stopped, he said.

“This was [an] uncomplicated way of measuring the errors and this dramatic effect is now being picked up by 44 hospitals in the States and will be piloted by one hospital here later in the year.”

James Nash, a director of infection prevention and control at East Kent Hospitals NHS Trust, explained that restricting the use of antibiotics is one way of helping to reduce the errors associated with them, and it can be effective in reducing cases of C difficile.

Cases of the infection fell dramatically twice in three Kent hospitals: first, when ceftriaxone was taken out of ward stocks in 2003 and secondly when other antibiotics were restricted alongside infection control measures in 2005 in response to an outbreak of the 027 strain of C difficile. There was huge opposition to the antibiotic restrictions among hospital staff, Dr Nash said, but it had significant benefits for patients, with C difficile rates falling even further in 2006.

Hospital pharmacists played a key role in this, said Dr Nash. “Changing the antibiotics is the most difficult thing to do and it needs the help of management and of the pharmacists in controlling access.”

But computer prescribing would be better than occasional audits. “Because we don’t have electronic prescribing in place we only have an approximate idea of what antibiotics are being given,” Dr Nash added.

Speaking to The Journal after the conference, Shilpa Jethwa, a specialist pharmacist in antibiotics at Northwick Park Hospital, London, said that electronic prescribing would be a helpful, but costly, intervention. “If it worked it would be really useful and a very good audit tool,” she said.

She added that electronic prescribing would cut the time needed to chase hospital notes and that a record of local resistance patterns would allow clinicians to prescribe the most appropriate treatment for patients.

Sir Liam Donaldson, England’s chief medical officer, is expected to write to NHS trusts to recommend they implement enhanced surveillance sampling for C difficile.

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