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PJ Online homeThe Pharmaceutical Journal
Vol 279 No 7472 p382-383
6 October 2007

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Letters to the Editor

Supply chain

Replies from
NICK QUIN, head of ethical buying at UniChem
PAUL SMITH, chief executive at Phoenix Healthcare Distribution Ltd
AMIT MAKWANA, managing director at Astellas Pharma Ltd

Problem obtaining Prograf capsules

From Mr R. H. Ferguson, MRPharmS

For some time now the availability of Prograf 1mg capsules from two of the UK’s main wholesalers (Phoenix and UniChem) has been sporadic. As a consequence, this means the service I provide to my patients has been adversely affected.

When I telephoned the manufacturer, Astellas Pharma Ltd, to find out why, it was explained that it had supplied enough product to wholesalers to meet the needs of patients in the UK and that wholesalers should have them in stock. I was told, however, I could order it direct from Astellas and it would be delivered via my normal wholesaler. I have had to resort to this process, but it simply is not good enough, since it means I receive the order a day or so later than I normally would, which inconveniences my patients.

In this case, it looks like community pharmacists and their patients are caught in the middle of some sort of struggle between manufacturers and wholesalers. And while this is fought-out (or ignored) behind the scenes, it is patients that suffer.

The current supply network is already experiencing a period of upheaval which threatens to disrupt supply and create confusion as one struggles to remember which wholesaler is dealing with which products, so this additional hassle is unhelpful.

What I would like to know from the wholesalers and Astellas is what is the cause of this problem and when will it be resolved?

Ross Ferguson
Glasgow

 

NICK QUIN, head of ethical buying at UniChem, responds:

UniChem is aware of this issue in relation to Prograf 1mg capsules and endeavours to work closely with Astellas Pharma Ltd to ensure that future continuity of supply for this medicine can be assured. We are happy to discuss this matter direct with Mr Ferguson, should he require further assistance.


PAUL SMITH, chief executive at Phoenix Healthcare Distribution Ltd, responds:

Following further investigation we find yet again that the issue is down to manufacturers limiting supply of product to wholesalers. In effect, Astellas Pharma Ltd limits our supply therefore we cannot fill our customers’ orders in a timely fashion. Astellas Pharma Ltd uses historical sales data to limit the supply chain but this is not carried out with any formula that takes into account the changing sales or growth through acquisition.

We are sorry that Mr Ferguson is experiencing difficulty in getting hold of this product and are concerned that this is inconveniencing both him and his patients. We share his frustration; this is not how the supply chain should work. We implore Astellas Pharma Ltd to review its current supply arrangements and make sufficient product available to allow us to do our job in ensuring that patients get timely access to medicines they need.


AMIT MAKWANA, managing director at Astellas Pharma Ltd, responds:

It has been brought to our attention that some patients have experienced difficulties accessing supplies of Prograf from their local pharmacies. Astellas Pharma Ltd takes complaints regarding the supply of its medicines seriously and has responded with urgency. The timely supply of all medicinal products is critical but this is particularly vital in the case of transplant medicines.

Given the fact that Prograf is prescribed for serious conditions where disruption of supply can have clinically important implications for the health and well being of patients, we have created a hotline for any pharmacist who is experiencing a supply difficulty, which will ensure they can receive Prograf direct from Astellas Pharma Ltd.

Clearly this is only an interim measure and we are currently urgently reviewing how to best ensure these transplantation medicines reach patients without delays.

We are committed to ensuring the essential continuity of the supply of these medicines to patients. If pharmacists have any issues related to the ordering of Prograf they should contact Astellas Pharma Ltd on 01784 419615 and ask for customer services.

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