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PJ Online homeThe Pharmaceutical Journal
Vol 279 No 7480 p614
1 December 2007

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Department of Health advises on immunoglobulin supply

Guidance on managing demand for and maintaining supply of immunoglobulin has been issued by the Department of Health. The guidance was developed by a working group of pharmacists, doctors, nurses and commissioners.

The DoH explains that there has been concern over the availability of immunoglobulin to the NHS for some time, due both to a global shortage and to the need for the UK to buy plasma from the US because of the risk of variant Creutzfeldt-Jakob disease in the UK. An ever-increasing demand for immunoglobulin due to the emergence of new indications has compounded this problem.

A national three-part initiative has been developed, including a demand-management plan, cross-specialty clinical guidelines and a database of users.

The guidance sets out a programme of actions for trusts, which includes setting up a local immunoglobulin assessment panel with pharmacist membership. The panel should develop local processes for reviewing applications for use of immunoglobulin, ensure all staff are aware of this process and collect data on trust usage, says the guidance.

The panel should determine what level of immunoglobulin is considered the safe minimum within the trust and set up intra-trust systems for communicating shortages.

The panel should also publicise use of the clinical guidelines and ensure they are circulated to doctors and pharmacists, it says.

The initiative aims to manage the supply of immunoglobulin so that availability is maintained for patients who depend on the product for survival and to improve consistency of immunoglobulin use.

A toolkit to help NHS trusts implement these actions has been developed and is available online

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