The Pharmaceutical Journal
Vol 279 No 7482 p671
15 December 2007

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Delaying Alzheimer’s disease

Cholinesterase inhibitors do not delay the appearance of Alzheimer’s disease or other forms of dementia, a review of data suggests.

Researchers looked at results from six clinical trials of donepezil, rivastigmine and galantamine to treat patients with mild cognitive impairment.

None of the trials showed that the drugs reduce the rate of progression from mild cognitive impairment to dementia (PLoS Medicine 2007;4:e338).