The Pharmaceutical Journal
Vol 279 No 7482 p673
15 December 2007

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Amiloride could be MS treatment

Amiloride reduces degeneration of nerve tissue in mice with a condition that mimics multiple sclerosis, according to research published online in Nature Medicine (11 November 2007).

The researchers identified that amiloride exerts its neuroprotective effect primarily by blocking the acid-sensing ion channel-1, therefore preventing the accumulation of calcium in nerve cells.