The Pharmaceutical Journal
Vol 280 No 7494 p329
22 March 2008

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Infective endocarditis advice

Best evidence suggests that prophylactic antibiotics should not be given to anyone with structural cardiac defects at risk of infective endocarditis who is undergoing interventional procedures (including dental procedures), the National Institute for Health and Clinical Excellence says in guidance issued this week to the NHS in England and Wales.

NICE’s recommendation is based on published evidence and expert consensus and is a significant change to current clinical practice.