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Vol 280 No 7498 p486
19 April 2008

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Athena

Yak-milk cheese for health

How the pill can be of help to IVF patients

Be good, do good, feel good

Fighting infection by computer


Yak-milk cheese for health

Yak-milk cheese Found mainly in the highlands of the Nepalese Himalayas, Indian Kashmir, Tibet, Mongolia and Bhutan, the yak is a large, shaggy, horned animal able to survive at temperatures as low as –40C and at altitudes where the atmospheric pressure is little more than half that at sea level.

The yak is a member of the subfamily Bovinae, which also includes the domestic cow and the buffalo, and, as with those species, its milk and milk products are part of the human diet in the regions where it is found. And researchers have now found that cheese made from yak’s milk has a better health profile than that from dairy cattle.

The nutritional value of dairy products is, in part, related to its fatty acid composition, in particular conjugated linoleic acid (CLA), trans-18:1 fatty acids and odd- and branched-chain fatty acids.

CLA is believed to have some anticarcinogenic properties as well as a range of positive health effects in experimental animal models, including beneficial effects on reducing body fat accretion, delaying the onset of type 2 diabetes, retarding the development of atherosclerosis, improving the mineralisation of bone and modulating the immune system.

However, all these benefits are debatable as scientific research is as yet inconclusive. CLA is found in ruminant food products due to the process of bacterial biohydrogenation of linoleic acid in the rumen.

Dr Mamun Or-Rashid at the University of Guelph, Canada, and colleagues compared the fatty acid content of cheese made from a Nepalese yak’s milk with a standard Canadian cheddar. In a paper published in Journal of Agricultural and Food Chemistry (March 2008), they found that the yak cheese had a lower overall fat content than the cow’s milk cheese. It also contained much higher levels of heart-healthy “good fats” such as CLA and omega-3 fatty acids.

These results suggest that cheese from yaks, grazed on Himalayan alpine pastures, may have a more healthy fatty acid composition compared to cheese manufactured from dairy cattle fed grain-based diets.

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How the pill can be of help to IVF patients

With a growing number of people in the UK undergoing in vitro fertilisation treatment, the implications of treatment on women’s stress, anxiety and sick leave needs to be addressed. Anything that can make IVF more convenient and efficient would go a long way in reducing the agony of an already heart-breaking process.

Paradoxically, one of the answers may lie in the contraceptive pill. Long used to retard ovulation, this tiny tablet may play a role in making IVF more convenient and less stressful.

The success of IVF depends in part on harvesting mature eggs from the woman. However, because clinics can be busy, patients may have difficulty in timing appointments to coincide with optimum egg harvesting.

In a study detailed in the January 2008 issue of the Journal of Assisted Reproduction and Genetics, Dr Haim Pinkas demonstrated that a two-week intervention treatment using a standard low-dose contraceptive pill can help time egg harvesting, making the IVF process more convenient for both doctor and patient.

The study was carried out on 1,800 women at the infertility and IVF unit at the Rabin Medical Centre in Israel. Although it is not the first study to document such effects, it is the largest of its kind. Normally doctors start the IVF treatment from the moment a woman gets her period. With the use of contraceptive pills, this can be delayed for 10 to 14 days after a period, allowing the treatment to be adjusted without compromising the ovarian response to stimulation.

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Be good, do good, feel good

Back in the fourth century BC, Aristotle wrote: “The many, the most vulgar, seemingly conceive the good and happiness as pleasure, and hence they also like the life of gratification. Here they appear completely slavish, since the life they decide on is a life for grazing animals.”

Aristotle produced many theories concerning what factors determine well-being including “doing good deeds”, and recent research suggests that he was right — that living a virtuous life leads to sustained well-being whereas hedonistic behaviour provides nothing beyond the pleasures of the moment.

In a paper published (March 2008) in Journal of Research in Personality, researchers assessed whether eudaemonic behaviour — ie, engaging in purposeful and well-meaning activities — is important to human functioning and a sense of well-being. The researchers asked 65 participants to complete daily diaries for either three weeks or four weeks.

These contained logs that indicated whether they had engaged in virtue-building activities, such as “gave money to a person in need”, “wrote out my goals for the future” and “listened carefully to another’s point of view”, or hedonistic behaviour such as “got drunk”, “had sex with someone I do not love” and “kept eating more than I intended of something just because it tasted so good”. Participants were also asked to comment on how they felt.

The results showed that eudaemonic behaviours had consistently stronger relations to well-being compared with hedonistic behaviours, suggesting that Aristotle had the right idea 23 centuries ago.

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Fighting infection by computer

Teaching the subject of biology through the medium of computer games seems the next step in our technology-friendly culture. Indeed this fluid and interactive medium may provide a new tone for science education.

Immune Attack is a new game developed in the US by Michelle Roper at the Federation of American Scientists, and accessible through the FAS website

At first, Immune Attack seems like any other video game. But, gone are the guns and missiles, the race-track and war zones; in Immune Attack, participants have the human body as their playground and drive through ominous blood vessels, fighting off villains with names like Pseudomonas aeruginosa, using biochemicals.

To play the game, users control a microscopic robot and navigate through a first-person 3D body, completing a series of stepwise missions to detect a bacterial infection. Once they find the perpetrators, they can activate certain immune cells. These missions follow real biological processes and show how immune cells are stimulated to kill the bacteria.

Designed as a supplemental learning tool, Immune Attack hopes to excite students about the subject, while also illuminating general principles and detailed concepts of immunology. It may also pave the way for new games, perhaps showing how heart attacks or conception occur and the impact of cancer.

Anyone care for a game?

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